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The Status and Problems in Developing Private Use Car for China

Guo Konghui

Strategic Study of CAE 2000, Volume 2, Issue 8, Pages 25-30

Abstract:

Should China develop its private use car? What kind of passenger car should China develop?Should China develop its own passenger car industry?What is the way out for China´s passenger car industry?And how to develop Chinese passenger car industry?convinced that the way to solve the“auto disaster”problems is not to put more restrains on the use

Keywords： Chinese auto industry private use car family use car state and problems

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The Largest Market for Civil Use of GPS ——Car Navigation System

Zhao Huiping

Strategic Study of CAE 2001, Volume 3, Issue 8, Pages 64-69

Abstract:

According to the principle of positioning a new car navigation system of triple accuracy which consistsAt present, the most wide civilian application of the GPS is the car navigation system.

Keywords： GPS car navigation intelligent transportation system (ITS)

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Epidemiological study of a von Hippel-Lindau family in northwest China

Jingyao Zhang, Dapeng Wu, Hong Ai, Jigang Bai, Shunbin Dong, Qinling Yang, Kai Qu, Lei Zhou, Xinsen Xu, Chang Liu

Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 378-385 doi: 10.1007/s11684-013-0276-0

Abstract: We encountered a large VHL family in northwest China and conducted a systematic screening of the familyFor the preliminary family screening, physical examination and abdomen B ultrasonography were performedA total of 63 lineal descendants in six generations were observed in the family (generations O, A, B,Therefore, follow-up checkups of the family should be focused on younger generations.Proper family screening protocols should be followed for the treatment of patients with VHL disease.

Keywords： von Hippel-Lindau disease epidemiology family screening pancreatic endocrine tumor

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The Advanced Gun Family——the birth of type 95 (5.8 mm) squad gun family

Duo Yingxian

Strategic Study of CAE 1999, Volume 1, Issue 2, Pages 57-61

Abstract: So after a short period of cooperated work, a new advanced squad gun family has been developed basedThis guns family were already used to equip the army assigned to Hong Kong in January, 1997 and shall

Keywords： squad gun family automatic rifle machine rifle assault rifle

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Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Frontiers of Medicine Pages 1006-1009 doi: 10.1007/s11684-023-1000-3

Abstract: Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Keywords： family craniofacial microsomia Identification novel mutations

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Family planning technical services in China

Shang-Chun WU

Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 285-289 doi: 10.1007/s11684-010-0097-3

Abstract: Family planning is a basic state policy in China.Technical services are the key measures for implementing the family planning policy.In order to ensure that people use safe, effective, and appropriate contraceptive methods based on thegovernment’s commitment, China has established countrywide family planning service networks down to

Keywords： family planning contraceptive method service delivery

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Discussion on the view of feeding patterns in new era’s family planning services

Yan Xiaoqing

Strategic Study of CAE 2014, Volume 16, Issue 5, Pages 24-30

Abstract: analyzes general reference volume，the impact of feeding-related factors as well as grass-roots demand for familyexplores the scientific and standardized service examination and evaluation system，enhances the grassroots family

Keywords： feeding patterns statistical analysis family planning services

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract:

T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advancedThe immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-TWe successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity incell culture and in murine xenograft model, which is comparable to standard CAR-T cells.

Keywords： CAR-T CRISPR-Cas9 LAG-3

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Thermal response of steel framing members in open car park fires

Xia YAN; Marion CHARLIER; Thomas GERNAY

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 9, Pages 1071-1088 doi: 10.1007/s11709-022-0879-0

Abstract: For open car park structures, adopting a performance-based structural fire design is often justifiedthis design approach requires an accurate assessment of temperatures in structural members exposed to carThis paper describes a numerical study on the thermal exposure on steel framing members in open car parkfire scenario, modeling approach, and use of galvanization.used to complete efficient structural fire designs based on the member sections, structure layout, and use

Keywords： open car park localized fire steel frame numerical modeling computational fluid dynamics

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SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4, Pages 645-658 doi: 10.15302/J-FASE -2020350

Abstract: Genome-wide analysis of the SOD gene family in various plant species has been conductedbut little is known about this gene family in watermelon (Citrullus lanatus).

Keywords： abiotic stress / expression analysis / phylogeny / SOD / superoxide dismutase / watermelon

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Electric Car Market Poised to Accelerate

Chris Palmer

Engineering 2021, Volume 7, Issue 2, Pages 136-138 doi: 10.1016/j.eng.2020.12.009

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: Clouston syndrome (OMIM #129500), also known as hidrotic ectodermal dysplasia type 2, is a rare autosomal dominant skin disorder. To date, four mutations in the GJB6 gene, G11R, V37E, A88V, and D50N, have been confirmed to cause this condition. In previous studies, the focus has been mainly on gene sequencing, and there has been a lack of research on clinical manifestations and pathogenesis. To confirm the diagnosis of this pedigree at the molecular level and summarize and analyse the clinical phenotype of patients and to provide a basis for further study of the pathogenesis of the disease, we performed whole-exome and Sanger sequencing on a large Chinese Clouston syndrome pedigree. Detailed clinical examination included histopathology, hair microscopy, and scanning electron microscopy. We found a novel heterozygous missense variant (c.134G>C:p.G45A) for Clouston syndrome. We identified a new clinical phenotype involving all nail needling pain in all patients and found a special honeycomb hole structure in the patients’ hair under scanning electron microscopy. Our data reveal that a novel variant (c.134G>C:p.G45A) plays a likely pathogenic role in this pedigree and highlight that genetic testing is necessary for the diagnosis of Clouston syndrome.

Keywords： Clouston syndrome whole exome sequencing GJB6 gene novel variant unique phenotype

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-celleffects, the causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR

Keywords： CAR T cells hematological malignancies review

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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function

Frontiers of Medicine doi: 10.1007/s11684-023-1006-x

Abstract: Here, a Pakistani family with parental consanguinity was presented, characterized with severe intellectual

Keywords： neurodevelopmental disorder autosomal recessive intellectual disability consanguinity spastic paraplegia hearing loss TMEM141

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The engineering and technology progress of CAR-CA

Zhao Qinping

Strategic Study of CAE 2009, Volume 11, Issue 10, Pages 25-31

Abstract: To meet the requirement of the design and manufacture of commercial aircraft in China, CAR-CA(collaborativeThis paper introduced the engineering and technology progress of CAR-CA, including the system architecture

Keywords： augmented reality collaboration cockpit design maintenance